Plots

RVEDD

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PA_sys

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mPAP

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Info

Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension
Sun, Xiao-Qing, et al. "Increased MAO-A activity promotes progression of pulmonary arterial hypertension." American journal of respiratory cell and molecular biology 64.3 (2021): 331-343.

NCBI Gene Summary for MAOB Gene

  • The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAOB Gene

MAOB (Monoamine Oxidase B) is a Protein Coding gene. Diseases associated with MAOB include Personality Disorder and Atypical Depressive Disorder. Among its related pathways are Disulfiram Pathway, Pharmacodynamics (Dopaminergic neuron) and Oxidation by cytochrome P450. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and electron transfer activity. An important paralog of this gene is MAOA.